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- Sex-specific challenges in cardiovascular disease among women: gaps in recognition, diagnosis, and management
- Mi-Seung Shin
- Cardiovasc Prev Pharmacother. 2025;7(2):50-54. Published online April 25, 2025
- DOI: https://doi.org/10.36011/cpp.2025.7.e8
- 4,950 View
- 36 Download
- 1 Citations
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Abstract
PDF - Despite being the leading cause of mortality among women, cardiovascular disease remains underrecognized and undertreated due to sex-related differences in clinical presentation, risk factors, and healthcare delivery. Women are often excluded from clinical trials, undergo fewer diagnostic evaluations, and are less likely to receive guideline-directed therapies. Additionally, female-specific risk factors, such as pregnancy-related disorders, early menopause, and autoimmune diseases, are frequently overlooked. Addressing these disparities through sex-specific risk assessment, increased clinician awareness, and inclusion of women in research is imperative to optimize prevention and treatment strategies and reduce cardiovascular disease-related morbidity and mortality in women.
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Citations
Citations to this article as recorded by
- Bridging the Gender Gap: The Urgent Need for Cardiovascular Data on Women
Jyotsna Maddury, Achukatla Kumar
Indian Journal of Cardiovascular Disease in Women.2025; 10: 165. CrossRef
- Bridging the Gender Gap: The Urgent Need for Cardiovascular Data on Women
- Clinical and preclinical obesity: cardiovascular implications of a new diagnostic paradigm
- Ga Eun Nam
- Cardiovasc Prev Pharmacother. 2025;7(2):21-27. Published online April 25, 2025
- DOI: https://doi.org/10.36011/cpp.2025.7.e6
- 28,113 View
- 105 Download
- 1 Citations
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Abstract
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- The traditional definition of obesity, relying solely on body mass index, inadequately captures individual health status and is insufficient for guiding therapeutic interventions. In January 2025, The Lancet Diabetes & Endocrinology Commission proposed a paradigm-shifting redefinition that introduces the concepts of “clinical obesity” and “preclinical obesity.” Clinical obesity is defined as a chronic, systemic illness characterized by excess adiposity resulting in functional impairments in tissues, organs, or overall individual health. In contrast, preclinical obesity involves excess adiposity without current functional impairment. This review examines the significance of this new diagnostic paradigm for cardiovascular disease prevention and risk assessment. From a cardiovascular perspective, the new framework offers several advantages: it facilitates personalized intervention strategies based on individual risk profiles, refines cardiovascular risk assessments by incorporating body fat distribution and functional parameters, promotes more efficient resource allocation, and shifts treatment goals toward functional improvements beyond mere weight loss. Although further research is required to evaluate practical implementation and long-term outcomes, this novel approach represents a substantial advancement in obesity management and cardiovascular disease prevention.
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Citations
Citations to this article as recorded by- Muscle Insulin Resistance Elicits Muscle Atrophy in Obesity
Omid Razi, Nastaran Zamani, Ayoub Saeidi, Marios Hadjicharalambous, Khadija Ayed, Anthony C. Hackney, Juan Del Coso, Ismail Laher, Giovanna Muscogiuri, Hassane Zouhal
Current Obesity Reports.2025;[Epub] CrossRef
- Muscle Insulin Resistance Elicits Muscle Atrophy in Obesity
- Diabetes mellitus and cancer
- Jae Won Hong
- Cardiovasc Prev Pharmacother. 2023;5(3):69-73. Published online July 27, 2023
- DOI: https://doi.org/10.36011/cpp.2023.5.e9
- 11,613 View
- 205 Download
- 2 Citations
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Abstract
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- Diabetes mellitus and cancer are the most common life-threatening illnesses worldwide. Previous epidemiological studies have suggested a strong association between diabetes mellitus and an increased risk of cancer. Potential biological mechanisms underlying this relationship include obesity, hyperglycemia, hyperinsulinemia, chronic inflammation, and oxidative stress. The most common diabetes-related cancers are pancreatic, hepatocellular, breast, endometrial, and colorectal cancer. Special attention should be paid to patients with diabetes through careful cancer screening and preventive anticancer strategies.
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Citations
Citations to this article as recorded by- Association between Diabetes Mellitus and Oral Cancer - A Systematic Review
Chetan Vinay Deshmukh, Arun Suresh Dodamani, Vibhuti Dilip Mistry, Mahesh Ravindra Khairnar, Mayuri Bhikaji Nepale, Snehal Sakharam Patil
Journal of Indian Association of Public Health Dentistry.2025; 23(3): 227. CrossRef - Repurposing metabolic regulators: antidiabetic drugs as anticancer agents
Yogita Dhas, Nupur Biswas, Divyalakshmi M.R., Lawrence D. Jones, Shashaanka Ashili
Molecular Biomedicine.2024;[Epub] CrossRef
- Association between Diabetes Mellitus and Oral Cancer - A Systematic Review
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