- Basic Concepts of a Mendelian Randomization Approach
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Tae-Hwa Go, Dae Ryong Kang
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Cardiovasc Prev Pharmacother. 2020;2(1):24-30. Published online January 31, 2020
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DOI: https://doi.org/10.36011/cpp.2020.2.e3
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- The Mendelian Randomization (MR) approach is a method that enables causal inference in observational studies. There are 3 assumptions that must be satisfied to obtain suitable results: 1) The genetic variant is strongly associated with the exposure, 2) The genetic variant is independent of the outcome, given the exposure and all confounders (measured and unmeasured) of the exposure-outcome association, 3) The genetic variant is independent of factors (measured and unmeasured) that confound the exposure-outcome relationship. This analysis has been used increasingly since 2011, but many researchers still do not know how to perform MR. Here, we introduce the basic concepts, assumptions, and methods of MR analysis to enable better understanding of this approach.
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Citations
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